FDA approves using Relenza to prevent flu

first_imgMar 29, 2006 (CIDRAP News) – The US Food and Drug Administration (FDA) today approved the use of the antiviral drug zanamivir (Relenza) to prevent—not just treat—influenza in adults and children aged 5 and older.Zanamivir, one of the two flu drugs known as neuraminidase inhibitors, was approved in 1999 for treating flu in people aged 7 and older, but not for prophylactic use. The other neuraminidase inhibitor, oseltamivir (Tamiflu), was approved for both treatment and prevention in adults and children from the age of 1 year.”This approval is a welcome addition to the available defenses against the flu,” Dr. Steven Galson, director of the FDA’s center for Drug Evaluation and Research, said in an FDA news release. “This new use offers the medical community another option to prevent and control influenza A and B.”Many countries are stockpiling oseltamivir, made by Roche, in the hope that it will offer some help in the next flu pandemic. Stockpiling of zanamivir, made by GlaxoSmithKline, has been less prevalent, but the United States is stocking up on both.”We have purchased, as of today, 4 million treatment courses of Relenza and 22 million treatment courses of Tamiflu,” Bill Hall, a spokesman for the Department of Health and Human Services, told CIDRAP News today. “We expect all of them to be in the stockpile by the end of this calendar year.”Hall said HHS is aiming for a total of 81 million treatment courses of the two antivirals by 2008, with zanamivir making probably up about 20%.Zanamivir is a powder that is inhaled by mouth with a “Diskhaler” device. Oseltamivir comes in capsule form.Four large, placebo-controlled studies have shown the effectiveness of Relenza for preventing flu, the FDA reported. In two trials, the incidence of flu in households whose members received the drug was 4.1%, versus 19.0% in households where people received a placebo.In a third trial, involving only adults, 2.0% of people in the Relenza group experienced flu symptoms, versus 6.1% of those in the placebo group, the FDA reported. In the fourth study, which involved mostly older adults, flu symptoms occurred in 1.4% of placebo group members and 0.2% of the treatment group.The FDA said zanamivir has not been found effective for preventing flu in nursing homes. Also, it is not recommended as a substitute for flu vaccine, the primary tool for preventing flu.The drug is not recommended for people who have asthma or other chronic respiratory disease, the FDA noted. After zanamivir’s initial approval, bronchospasm, in some cases fatal, was reported in some patients, most of whom had asthma or chronic obstructive pulmonary disease, the agency said.See also:Mar 29 FDA news releasehttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108622.htmFDA background information on Relenzahttp://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm183783.htmGlaxoSmithKline’s detailed information on Relenzahttp://us.gsk.com/products/assets/us_relenza.pdfCIDRAP overview on use of antiviral agents for pandemic flulast_img read more

Saints eyeing Vilhena and Djuricic

first_img Koeman decided to make those moves after Cork rejected a new contract at Southampton in favour of a deal at Sunday’s opponents Swansea. “For a coach, he is always a player good to have in the squad because he can play in different positions in midfield,” the Saints boss said. “If you look back to the first part of the season, he was not starting. “If I have all the players available, he is not one of the three players in the midfield. “But he is an experienced player and he is a player who knows his situation and when he came into the team he was doing well. “It is always important to have these kind of players for the coach, but, finally, the player has decided not to accept the contract and that means a different situation for the club, for the coach.” Koeman was surprised by the amount of time it took Cork to come to his decision, having first opened discussions two months ago, but understands the player’s decision. “We believe that we offered the player a very good contract and the player told me that it wasn’t about the numbers in the contract,” he added. “It wasn’t about the money, but about his feeling, about maybe not playing enough. “Okay, I can’t guarantee nobody they will play more. It is always competition that you have in your squad.” Cork has been a bedrock at Saints since 2011, with his exit the latest which leaves the team looking vastly different to when Jay Rodriguez and Sam Gallagher last featured. Both have missed the entire campaign to date so far with injury, although the latter is at last closing in on a return. “Sam Gallagher is starting training with the under-21s,” Koeman said. “I think that it is good for the player to start at a little lower level, having been a long-time out of training. “With Jay, there is not any other positive news. He has continued working but I can’t say now that he is two weeks or three weeks or one week closer to team training, no.” Now, the Dutchman is looking to bring in a new player, with his key targets Benfica’s Djuricic – a Serbia international who spent the first half of the season on loan to Mainz – and Vilhena at former club Feyenoord. “On principle we are looking for a player that can play in different positions,” Koeman said. “Okay, we have our interest in Djuricic and he can play one of the positions in midfield, he can play on the left in a wing position in a free role, he can play in the right-wing position in a free role. “That is the best – to bring in a player who can play in different positions. “The case of Vilhena is that the management of the player called me and they were afraid about his situation at Feyenood. “I said ‘okay, I like the player’. First, the player is 20-years-old, he played a lot in Holland, he played 80-85 per cent of all the games in two seasons when I was the coach in Feyenoord. “It is part of our philosophy in the club to have young players. That’s not a risk. “I don’t know what level he will reach, but at least he is now I think at a higher level than most of the under-21 midfielders. That’s always what you look for.” Southampton manager Ronald Koeman wants to bring a utility player in before the transfer deadline, with Tonny Vilhena and Filip Djuricic top of his shopping list. Press Association This month, like so many winter windows before it, has been quiet at St Mary’s, with the loan addition of Eljero Elia the only arrival at the top-four contenders. That is how Koeman had planned to keep it until injuries began to mount and midfielder Jack Cork rejected a new contract in favour of a move to Swansea. last_img read more

#TalkUp: Should Protests Stop Now That the Minneapolis Police Officers Have…

first_imgAkeem Horatio, FL – “In no way should we stop protesting. We must protest by any means necessary as we have seen too many times officers either not being charged or be charged and not convicted for their horrible crimes. Stopping now will only allow those prosecuting to see that they can get away with another one walking. The protests outside of the trials also push those in power to make the changes we are requesting. We do not only want convictions we want to change/destroy the systems that make these trials necessary in the first place. Once we see enough of those changes in place, then and only then should we cease.” Camille DJ Nial, FL – “My short answer to this question is yes. I say yes because I believe that our voice and our action led to the arrest of those officers. At this point, these protests are not just about George Floyd. These protests are about Emmett Till, Trayvon Martin, Philando Castile, Sandra Bland, and the many others that have been killed due to the color of their skin. These protests are also for you, me, our family, our children. These protests represent an oppressed people asking for equal rights and justice. These protests represent the voice of the voiceless. These protests are out of years of frustration, boiling inside us.” Akeem, FL – “The battle to some may be won but the war is far from over. It takes intense protesting to get four officers arrested and charge in America for what we all know is immoral disgusting. Now the target is the homes—the mindset for those who hear racial discrimination with the comfort of their own families. The protest needs to take a new direction in my opinion. It needs to hit the voting booths. Voting on local government is just as or even more important than the presidential election. Now we need to investigate those we have in place to look out for us and set policies in place that were supposed to protect “us” and see why they failed. We need to vote out those that do not belong and place those in that do. The same next step after bringing awareness (protesting) is taking action… (voting) have several people out there ensuring we are voting for the right person or just ensuring we are registered. To answer the question, no, the protest should not stop and should actually be enhanced.” DJ Stunna, FL – “Yes, they should continue because this is just a battle within the war. In order to create change in the police force, the disruption should continue until we are pleased. People coming together because the police will continue to racially profile black people. The protests are working and have gotten us results. Protesters are the reason the other officers actually are being held accountable for their actions.” Amber – “Yes, it should continue…We have not accomplished our goal as yet, we only got a few dirty cops arrested. We need laws to be put in place to make them more accountable for their actions. Some believe it’s better training, I believe it’s accountability and punishment that’s needed.” Horatiocenter_img Viveca, Miami – “I believe the protests were brought on because of the non-arrests of the other three officers and due to the non-action of the police force. The protests have brought attention to the Black Lives Matter movement and may make a change. But change will only happen if we all, black, brown, white people, and all ethnicity take it upon themselves to be active for the cause. If protests can continue in a peaceful manner and without incidents, then yes, the protest can continue.” Camille – “I honestly think the protesting should stop now because they finally charged the officers that killed Floyd. Well until we see how many years they will have them in prison then I feel like It should officially end because justice was served.” DJ Stunna Should protests stop now that the four former Minneapolis police officers have been arrested and charged in the murder of George Floyd? Amber DJ Niallast_img read more

Tipstrr announces new cryptocurrency at #bofcon2018

first_imgShare Submit Related Articles Tipstrr launches new in-house affiliate program October 4, 2018 Share StumbleUpon Tipstrr acquired by Natural Intelligence December 10, 2019 SBC Sponsorship Forum drives Betway’s Deportivo Alavés deal August 14, 2018 Tipstrr, the online betting tips service, announced a new sports tipster-focused cryptocurrency yesterday, at the Betting on Football 2018 conference.Named Tipcoin, it has been launched to alleviate a number of issues that had been identified by the West Midlands-based firm. Andy Jones, Tipstrr Technical Director, described the thought process behind the decision: “So the biggest barrier our users have, is the fact that the more bets you place, the more effort it is. You might be going to the supermarket but you need to place that bet. Time is important, but if you follow 50 tipsters you can make a lot of money, if you have the time. “So we’re breaking that barrier down now, by launching a new cryptocurrency that will enable us to allow for automated betting based on tipsters. “What it does is allows users to create their own hub of betting syndicates, based on their own risks, choose their own staker plans, choose their own risks and rewards. “The way that the cryptocurrency comes in to it, we’re gonna be offering a way for users to bid for unlimited access across the site each week. At the start of the week users can spend Tipcoins, they can bid on the amount of Tipcoins, and the top 10% – there or there about – will get full access across the sites. “So that’s gonna mean the people that want it most, the people who bid the most amount of money, will get access to every single tipster, from that they can then use parameters to decide which bets they place, which will be automatically placed.”Jones also spoke enthusiastically about this year’s Betting on Football, and why he thought the conference was ideally suited to Tipstrr’s big announcement.“It’s got the perfect audience for us – there’s a lot of people interested in betting on football! It’s been a really enjoyable experience so far and we’ve had the chance to speak to a lot of interesting people.”last_img read more

MAYOR WISHES STUDENTS GOOD LUCK AS HIS TWO DAUGHTERS START LEAVING CERT

first_imgDonegal Mayor Cllr Frank McBrearty Jnr has wished all students taking their Junior and Leaving certificate exams this year his best wishes and good luck.Mayor Frank McBreartyThe Raphoe politician has revealed he has two daughters sitting the Leaving Cert which starts tomorrow.“Exam time is stressful for all but remember at this point the work has been done and all you can do now is do the best you can. “If you are feeling under pressure or stressed do not hesitate to seek support from parents, family or friends. Take care of yourself by eating and sleeping properly during this exam period and take regular study breaks and exercise.“I have two daughters doing their Leaving certificate and have told them that even though these exams are important, they need to keep things in perspective and remember that they will not define their lives. Once again best wishes and good luck to all,” he said.MAYOR WISHES STUDENTS GOOD LUCK AS HIS TWO DAUGHTERS START LEAVING CERT was last modified: June 4th, 2013 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:examsFrank McBreartyJunior CertLeaving certlucklast_img read more

Dortmund chief rules out Pulisic Weigl January exits

first_imgBorussia Dortmund sporting director Michael Zorc announced that Christian Pulisic will remain at the club after January, while also hinting the same for Julian WeiglThe young duo have both been linked with winter moves away from Dortmund amid struggles to gain regular game time under coach Lucien Favre.Weigl, who was previously linked with a switch to Manchester City earlier this year, has fallen behind summer recruit Axel Witsel in the Dortmund midfield pecking order.Meanwhile, ex-USA star Alexi Lalas has urged Pulisic to leave Dortmund in favour of a transfer to a bigger European club.Chelsea and Liverpool have been linked with moves for Pulisic recently, but Dortmund insists the American is going nowhere.Jadon SanchoMerson believes Arsenal should sign Sancho Manuel R. Medina – September 14, 2019 Borussia Dortmund winger Jadon Sancho might be the perfect player to play for the Gunners, according to former England international Paul Merson.“We won’t let any important players, who are indispensable for achieving our sporting goals, leave this winter,” Zorc told Bild.“I’m strongly assuming that Christian (Pulisic) will still be wearing the BVB jersey in February.”Although former Manchester United midfielder Shinji Kagawa is being tipped to make a January exit after being left out of Dortmund’s 2-0 Champions League win at AS Monaco.The Japan international recently expressed a desire to try his luck at La Liga football before the end of his playing career.last_img read more

Twinkle Sharma case Bollywood reacts with shock after 3yearolds murder in Aligarh

first_imgTwinkle Sharma was murdered in Aligarh after her parents couldn’t repay a loan of Rs 10,000.TwitterThree days after toddler Twinkle Sharma went missing in Aligarh her mutilated and burnt body was found in a dumping ground in Tappal, Aligarh district, Uttar Pradesh, on June 2. Twinkle, aged between 2.5 to 3 years, was brutally murdered by accused Mohammed Zahid, according to reports. The motive behind the murder was a meagre sum of Rs 10,000 that Twinkle’s parents owed Zahid.Bollywood has reacted with shock after the 2.5-year-old’s murder in Aligarh. Zahid and his accomplice Aslam were arrested on June 4 by the Aligarh Police, who have as of now ruled out rape. Zahid reportedly admitted to killing the child by choking her with a dupatta (stole). The child’s partially burnt body was found in a bag with her eyes gouged out.The murder has sent shockwaves across the country, with some people giving a communal angle to it, including actress Koena Mitra. Bollywood actors like Abhishek Bachchan, Ayushmann Khurrana, Raveena Tandon, Sunny Leone, Sidharth Malhotra, Gul Panag, Twinke Khanna, Akshay Kumar, Anupam Kher, Sanjay Dutt, Riteish Deshmukh, Genelia Deshmukh, Boman Irani, Arjun Kapoor, Sonam Kapoor and some others have reacted strongly to the heinous act.Some people on Twitter questioned the silence of Sonam Kapoor, Kareena Kapoor and Swara Bhasker on the murder case, when the actresses were pictured holding placards during the Kathua rape case of Ashifa. Sonam Kapoor posted a fresh message but got further trolled, even by filmmaker Ashoke Pandit. It is sad that the two cases of Twinkle Sharma and Asifa are being given a communal angle. Kareena Kapoor, Sonam Kapoor and Swara Bhasker protest Kathua rape.TwitterHere’s what Bollywood celebrities have said on Twitter after the Twinkle Sharma murder came to light:Akshay Kumar: Horrified, upset and angry to know about baby #TwinkleSharma! This is definitely not the kind of world we want for our children. We need immediate and strictest punishment for such a heinous crime. #JusticeForTwinkle.Twinke Khanna: It is heartbreaking to hear about the horrific murder of the two and a half year old little girl In Aligarh. I would request @smritiirani to ensure that swift action is taken against the perpetrators of this heinous crime. #JusticeForTwinkle.Sonam Kapoor: What has happened to baby twinkle is. Heartbreaking and horrific. I pray for her and her family. I also urge people to not make this into a selfish agenda. This is a little girls death, not a reason to spread your hate.Raveena Tandon: The horrible, barbaric rape,murder of a 3 year old In Aligarh,the criminals,who gouged her eyes, mutilated her body,depraved evil,inhuman & barbaric. Must Hang. The law must act fast! #justicefortwinkle @smritiirani #twinklesharma.Abhishek Bachchan: Just so disgusted and angered hearing about #TwinkleSharma. How can somebody even think of doing such a thing?!?! Speechless….Ayushmann Khurrana: This is inhuman and barbaric.. My prayers for her family. Justice must be served! #TwinkleSharma.Sidharth Malhotra: Extremely disturbed by the news of #TwinkleSharma. It’s scary to be living in a world where even innocent children are not safe. I urge our authorities to take action to ensure that such a heinous crime is never repeated again! #JusticeForTwinkleSharma.Gul Panag: That we live in a country where even toddlers aren’t safe, fills me with horror. That #TwinkleSharma had a her life snatched away in this cruel, barbaric manner, makes me feel capital punishment is not enough for the sick, depraved culprit who did this to her.Sunny Leone: Im sorry Twinkle that you had to you live in a world where Humans no longer understand Humanity!!!! May God look over you for Eternity as you are an Angel !!!! #ImSorry.Sanjay Dutt: Disturbed and hurt to hear the news about #TwinkleSharma. I urge our authorities to take necessary action! #JusticeForTwinkle.Anupam Kher: Angry, horrified, ashamed and deeply saddened beyond words at the barbaric rape of the three year old #TwinkleSharma. The rapist should be hanged in public. No other punishment is enough for this heinous crime. I demand #JusticeForTwinkleSharma .Arjun Kapoor: The barbaric rape and murder of #TwinkleSharma is a shame on humanity. Justice must be served.Riteish Deshmukh: Deeply pained, saddened & shocked. We as a society have failed little #TwinkleSharma – my heart goes out to her family & loved ones. What kind of an unsafe world are we creating for our children. Strictest punishment & immediate justice is the only way to reduce these crimes.Genelia Deshmukh: It’s horrific, I am absolutely angered by what’s happening to the women and more so the little girls in our country.. #TwinkleSharma we have failed you and a zillion like you time and time again .. people responsible of such crimes should be hanged publicly.. Can’t imagine the plight and the pain of #TwinkleSharma’s family and loved ones.. I’m so so sorry #JusticeForTwinkleSharma .Boman Irani: Is our planet spinning in the opposite direction? Is this what humans were meant to be? Whatever the answer. NO PUNISHMENT IS TOO HARSH. #JusticeForTwinkleSharma #TwinkleSharma .The Aligarh Police is posting latest updates on the case on social media. The latest Aligarh Police statement on the Twinkle Sharma murder case is as follows. Aligarh Police statement on Twinkle Sharma murder case.TwitterIm sorry Twinkle that you had to you live in a world where Humans no longer understand Humanity!!!! May God look over you for Eternity as you are an Angel !!!! #ImSorry— Sunny Leone (@SunnyLeone) June 6, 2019What has happened to baby twinkle is. Heartbreaking and horrific. I pray for her and her family. I also urge people to not make this into a selfish agenda. This is a little girls death, not a reason to spread your hate.— Sonam K Ahuja (@sonamakapoor) 7 June 2019#JusticeForTwinkle@aajtak @abpnewshindi @ndtv @ANINewsUP @BBCBreaking @ZeeNews @WeUttarPradesh @ANINewsUP @NDTV_24X7 @TimesNow @timesofindia @brajeshlive @WeUttarPradesh @dibang @chitraaum @anjanaomkashyap @Uppolice @dgpup @adgzoneagra @digrangealigarh pic.twitter.com/UKz7nGpd6t— ALIGARH POLICE (@aligarhpolice) 7 June 2019Dear Women, you can change the world by not giving birth to morons. When you can’t raise them, don’t create them!Dear lawmakers, we need dangerous punishments for Acid attacks and Rapes. Crimes against girls should come to an end!!#JusticeForTwinkle #Aligarh #TwinkleSharma pic.twitter.com/vuxbgfcG5S— Koena Mitra (@koenamitra) 6 June 2019Hindus have the responsibility to remain secular I guess, hence no outrage for you. I am Hindustan. A proud Hindu. I’m not liberal enough to support your Rapists.I’m no secular from today. With you and yours…. #TwinkleSharma #Aligarh #Mohammedjahid pic.twitter.com/W58PlUVy8o— Koena Mitra (@koenamitra) 6 June 2019Angry, horrified, ashamed and deeply saddened beyond words at the barbaric rape of the three year old #TwinkleSharma. The rapist should be hanged in public. No other punishment is enough for this heinous crime. I demand #JusticeForTwinkleSharma . pic.twitter.com/7EwCTQxsUh— Anupam Kher (@AnupamPKher) 6 June 2019 आज दिनांक- 08-06-2019 को @sspaligarh @ips06akash महोदय द्वारा थाना टप्पल क्षेत्र में हुए ए लिटिल गर्ल मर्डर केस मे अपहरण व हत्या के सभी आरोपी गिरफ्तार, के सम्बन्ध में दी गयी बाईट ।@Uppolice @dgpup @adgzoneagra @digrangealigarh pic.twitter.com/p5fMeoPEfu— ALIGARH POLICE (@aligarhpolice) 8 June 2019last_img read more

More pain ahead Indian banks stare at Rs 25 trln new bad

first_imgAn employee works on electric pylons at a power station in Greater Noida on the outskirts of New Delhi June 8, 2012 (representational image).Reuters fileThere is more pain lurking for India’s troubled banking sector with the lenders staring at potential bad loans of $38 billion (Rs 2.5 trillion) from the power sector, according to a report.”Of the $178 billion (around Rs 11.7 trillion) of debt of the power sector, $53 billion are already under stress (primarily to the generation sector) and of this, as much as $38 billion have the potential of being written-off as bad loans,” the Bank of America-Merrill Lynch said in a report on Wednesday.The report is based on the fact that as much as 71 gigawatt of private sector coal-based projects are facing bankruptcy filings at various National Company Law Tribunals, implying probable resolution from June 2019 and it expects an average 75 percent write-off in these loans.Power sector has been a major concern in India, due to decline in fiscal health of State Electricity Boards. The debt-laded sector is struggling to service and pay off billions of dollars in loans, posing a major debt risk for the banking sector.In order to rescue the sector, the government is trying to revamp the space by releasing the projects that have been stuck due to major need of funds but failure to enact and implement supplemental laws at the state level have continued to pose a hindrance.As per the BofA-ML report, of the $178 billion loan, the distribution companies have $65 billion, generation companies have $7 billion, and transmission firms have a debt burden of $36 billion.Brokerage estimates the power generation sector accounts for 53 percent of the debt on domestic bank watchlists, followed by non-banking finance companies (NBFCs) at 35 per cent and the balance from the states.It also states that tariff hikes are not the way forward for the sector to turnaround as already tariffs for industrial and commercial consumers, who constitute 37 percent of demand, are very high compared to its regional peers.But the report is critical of the reforms introduced to address inefficiencies saying they expect limited progress.last_img read more

Judge Bars Trump Administration From Detaining Asylum Seekers Without Cause

first_img To embed this piece of audio in your site, please use this code: X Listen AP Photo/Susan Walsh, FileA federal judge has blocked the Trump administration from arbitrarily detaining asylum seekers at the border. The ruling comes in response to a suit filed in March by the American Civil Liberties Union.U.S. District Judge James E. Boasberg ruled the Trump administration was violating a 2009 Immigration and Customs Enforcement directive. Under that rule, ICE must grant parole to any asylum seeker who passes what’s known as a “credible fear interview.” That’s an interview used to determine if they have a legitimate reason to fear persecution or torture if they’re deported.  Geoffrey Hoffman, director of the University of Houston Law Center’s Immigration Clinic, spoke with Houston Matters. “In 2009, about 90 percent were actually released,” said Hoffman. “And then under the Trump administration, according to the stats that were given to the federal judge, about 100 percent were denied parole in various field offices, including El Paso, Philadelphia and Newark.”Houston Matters contacted the Justice Department for a response to the ruling, but the department declined to comment. 00:00 /00:51 Sharelast_img read more