Red Blood Cells Are Master Contortionists

first_imgBiophysicists have analyzed why red blood cells are able to squeeze through tight spaces on their journeys through our tissues, reports the UCSD Jacobs School of Engineering.  Their membranes contain a network of 33,000 hexagons arranged in a complex geodesic dome formation.  Each hexagon vertex is joined with flexible lines to a central maypole-like proto-filament, giving it the ability to twist and contort without breaking.  This contortionist ability serves another purpose beyond just enabling the cell to get through tight spaces: it also helps squeeze out the oxygen into the tissues.  Despite being twisted, folded, flattened or stretched, the geodesic structure permits the cell to pop back into its familiar biconcave shape.    The press release states, “Their paper in Annals of Biomedical Engineering uses aeronautical terms commonly used to describe the changing position of an airplane to explain how the six attached spectrin fibers make a proto-filament swivel and flip.”  Science Now took note of this study on “bendable blood.”The shape of red blood cells is also the optimum for maximizing surface area (for diffusion) without sacrificing volume (for payload).  If they were rigid disks, they would get stuck, starving tissues of oxygen and causing death.  As you work today, think about those little erythrocyte spelunkers making their rounds, delivering the goods from that last breath of air to every cubic micrometer of your body.  The Creator thought of everything.(Visited 8 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Best Construction Details for Deep-Energy Retrofits

first_img Sign up for a free trial and get instant access to this article as well as GBA’s complete library of premium articles and construction details. A collection of experts working on deep-energy retrofits recently attended a brainstorming session to share design tips and propose topics for further research.The conference, formally titled the “Expert Meeting for Details for Deep Energy Retrofits,” was held in Boston on March 12. The meeting was funded by the Department of Energy’s Building America program and hosted by the Building Science Corporation.Several experts — including two principals of the Building Science Corporation, John Straube and Joe Lstiburek — gave presentations. Straube discussed retrofit options for walls; Lstiburek covered roofs; and their colleague Kohta Ueno discussed basements. Paul Eldrenkamp, a remodeler from Newton, Mass., shared his experience with several deep-energy retrofit projects, while energy consultant Marc Rosenbaum shared questions designed to stimulate new approaches to reducing residential energy use.I’ve mined the published report of the proceedings for the following tips and pithy quotes.If you’re adding rigid foam to your wall, put it on the exteriorDr. Straube noted the advantages of exterior over interior wall foam. Thick walls without exterior foam usually have cold OSB sheathing. That’s bad: cold OSB is a potential condensing surface — and damp OSB can rot fast. (By encouraging drying, a ventilated air gap between the OSB and the siding can go a long ways toward reducing the risks associated with cold OSB. But adding exterior foam is the best way to eliminate the risk of condensation.)Among Dr. Straube’s points:After his presentation, Straube answered questions.Q: “Can a Larsen truss exterior wall assembly filled with cellulose insulation be used to provide significant insulation to the exterior of a structure?”Straube’s response: “With a Larsen truss, cellulose, and sheathing on the outside, the sheathing is actually colder than ambient air because of radiation transfer.” (Straube was referring to nighttime radiation transfer,… This article is only available to GBA Prime Memberscenter_img Start Free Trial Already a member? Log inlast_img read more

5 Things To Do In Wilmington On Wednesday May 22 2019

first_imgWILMINGTON, MA — Below are 5 things to do in Wilmington on Wednesday, May 22, 2019:#1) Free Ice Cream Truck At New England Dental GroupNew England Dental Group (206 Ballardvale Street) is hosting an Ice Cream Truck Event from 11am to 3pm with free ice cream and a chance to enter a free teeth whitening raffle.#2) Book Store Next Door OpenThe Friends of the Wilmington Memorial Library’s Book Store Next Door (183 Middlesex Avenue) is open from 10am to 4pm. All books are $2 or less!  Every penny of every sale benefits the Wilmington Memorial Library. Learn more HERE.#3) Wilmington School Committee MeetingThe Wilmington School Committee meets at 7pm in the High School’s Large Instruction Room. Read the agenda HERE.#4) Music & More At Wilmington LibraryThe Wilmington Memorial Library (175 Middlesex Avenue) is hosting Music & More at 6:30pm. Bernadette Baird presents music and movement for toddlers and young children through age three. Sing, play musical instruments and dance. Ages 1-3. Register HERE.#5) Teen Board Game Club MeetingThe Wilmington Memorial Library (175 Middlesex Avenue) is holding a Teen Board Game Club Meeting from 6:30pm to 8:30pm. Looking to learn, play, or create fun board games? Bring your favorite game or latest prototype and we’ll play together. Students and their adults welcome. Limited space. Grades 6 – 12. Register HERE.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… Related5 Things To Do In Wilmington On Wednesday, August 28, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Wednesday, July 24, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Wednesday, July 31, 2019In “5 Things To Do Today”last_img read more

Policybazaar enters unicorn club with SoftBankled 200 million funding

first_imgSoftBank Group Corp Chairman and CEO Masayoshi Son attends a news conference in Tokyo, Japan, February 8, 2017. [ File photo]Reuters filePolicybazaar became the latest entrant in the Unicorn club of the Indian startup segment after raising more than $200 million from investors led by SoftBank Group’s Vision Fund on Monday. The online financial services portal run by EtechAces Marketing and Consulting Pvt. Ltd has been valued at more than a billion dollars, the company said on Monday.It became the second Indian startup in as many weeks after Swiggy, a food delivery tech startup which joined the Unicorn club post raising $ 210 million from DST Global. All the existing Indian investors except Premji Invest participated in the current round of funding. EtechAces, which runs PolicyBazaar and Paisabazaar.com, counts Temasek, Tiger Global Management, True North, Premji Invest as existing investors.In a statement Yashish Dahiya, co-founder and chief executive said, “SoftBank’s culture of backing disruptive businesses and industry leaders with long-term capital investment gels well with our own values and vision of creating a transparent and empowering financial products marketplace. We hope to gain a lot from their global footprint and experience.”The company also said that the growth in insurance purchases digitally will enable it to grow at an annual average rate of 80 percent over the next three years to a total of 10 million transacting customers by 2020. According to Boston Consulting Group’s estimates, digital influence on insurance purchases will grow to 50 percent for life insurance and 75 percent for general insurance by 2020.Policybazaar is a Gurugram based company founded in 2008, which offers online services to consumers to compare and purchase insurance policies. It currently accounts for nearly 25 percent of India’s life cover, and over 7 percent of India’s retail health insurance business. The online insurance platform competes with Sequoia Capital-backed BankBazaar (A&A Dukaan Financial Services Pvt. Ltd), new entrant Coverfox, which recently raised $22 million, besides Fairfax Financial Holdings-backed Digit Insurance, and start-up Acko, which raised $12 million from Amazon in May this year.last_img read more

3 including siblings die taking excessive liquor

first_imgNarayanganjThree young men died reportedly after taking excessive liquor during a pre-wedding party at Narayanganj’s Siddhirganj on Friday noon, reports UNB.The deceased are Ashique Hossain, 20, son of Abul Hossain and two brothers –Akib Uddin, 24, and Rasel, 28–sons of Alauddin Akhter of the area.Locals said the trio and some others consumed foreign-made alcohol during a ‘holud’ ceremony on Wednesday night. At one stage, the victims fell sick, they added.Later, they were taken to Dhaka Medical College Hospital on Thursday morning.The victims died on Friday noon while undergoing treatment at DMCH, said Shahin Shah Parvez, officer-in-charge of Siddhirganj police station.The bodies were kept at hospital morgue for autopsy, the OC added.last_img