FDA approves using Relenza to prevent flu

first_imgMar 29, 2006 (CIDRAP News) – The US Food and Drug Administration (FDA) today approved the use of the antiviral drug zanamivir (Relenza) to prevent—not just treat—influenza in adults and children aged 5 and older.Zanamivir, one of the two flu drugs known as neuraminidase inhibitors, was approved in 1999 for treating flu in people aged 7 and older, but not for prophylactic use. The other neuraminidase inhibitor, oseltamivir (Tamiflu), was approved for both treatment and prevention in adults and children from the age of 1 year.”This approval is a welcome addition to the available defenses against the flu,” Dr. Steven Galson, director of the FDA’s center for Drug Evaluation and Research, said in an FDA news release. “This new use offers the medical community another option to prevent and control influenza A and B.”Many countries are stockpiling oseltamivir, made by Roche, in the hope that it will offer some help in the next flu pandemic. Stockpiling of zanamivir, made by GlaxoSmithKline, has been less prevalent, but the United States is stocking up on both.”We have purchased, as of today, 4 million treatment courses of Relenza and 22 million treatment courses of Tamiflu,” Bill Hall, a spokesman for the Department of Health and Human Services, told CIDRAP News today. “We expect all of them to be in the stockpile by the end of this calendar year.”Hall said HHS is aiming for a total of 81 million treatment courses of the two antivirals by 2008, with zanamivir making probably up about 20%.Zanamivir is a powder that is inhaled by mouth with a “Diskhaler” device. Oseltamivir comes in capsule form.Four large, placebo-controlled studies have shown the effectiveness of Relenza for preventing flu, the FDA reported. In two trials, the incidence of flu in households whose members received the drug was 4.1%, versus 19.0% in households where people received a placebo.In a third trial, involving only adults, 2.0% of people in the Relenza group experienced flu symptoms, versus 6.1% of those in the placebo group, the FDA reported. In the fourth study, which involved mostly older adults, flu symptoms occurred in 1.4% of placebo group members and 0.2% of the treatment group.The FDA said zanamivir has not been found effective for preventing flu in nursing homes. Also, it is not recommended as a substitute for flu vaccine, the primary tool for preventing flu.The drug is not recommended for people who have asthma or other chronic respiratory disease, the FDA noted. After zanamivir’s initial approval, bronchospasm, in some cases fatal, was reported in some patients, most of whom had asthma or chronic obstructive pulmonary disease, the agency said.See also:Mar 29 FDA news releasehttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108622.htmFDA background information on Relenzahttp://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm183783.htmGlaxoSmithKline’s detailed information on Relenzahttp://us.gsk.com/products/assets/us_relenza.pdfCIDRAP overview on use of antiviral agents for pandemic flulast_img read more

COVID crisis could worsen existing UK inequality, think tank says

first_imgTopics : “Government will need to be on the front foot in laying the groundwork for a strong and inclusive recovery even while still dealing with the immediate crisis,” said IFS deputy director Robert Joyce, who co-wrote the report.Reforms to consider included providing better training for workers, protecting small businesses, and catch-up teaching for children, especially from poorer families.The IFS report saw some upsides from the shutdown, including increased remote working which could help mothers’ careers while fathers spent more time with their children than before.Remote working could also help spread high-paid and high-productivity jobs away from London, addressing Britain’s regional productivity disparities.The IFS’s findings chimed with other research by academics who found black, Asian and minority ethnic people in Britain, and those with fewer qualifications, were hit harder by job losses than the population as a whole.The reports have come as the global protests at the killing of George Floyd in Minneapolis have put renewed focus on the wider economic inequalities facing black people.  The coronavirus crisis is exposing Britain’s existing inequalities – between low and high earners, young and old workers and for ethnic minorities – which could be aggravated without reforms, a leading think tank said on Thursday.People on low wages are most at risk of losing income and their jobs because of the COVID-19 shutdown, while a gap in death rates between rich and poor neighborhoods has widened, the Institute for Fiscal Studies said.British people of Pakistani or Bangladeshi heritage are most likely to work in sectors affected by the coronavirus shutdown. Black people have contracted COVID-19 at far-above-average rates, reflecting how they are more likely to be in jobs with a greater risk of exposure to the coronavirus, the IFS said.last_img read more

Foreign arrivals plunge 60% in first half of 2020

first_imgThe number of foreign tourists arriving on Indonesia’s shores plummeted 59.96 percent to 3.09 million in the first half of the year as the COVID-19 pandemic brought tourism to its knees, Statistics Indonesia (BPS) reported Monday.In June, foreign visitor numbers were down 88.82 percent year-on-year (yoy) to around 160,300. The month-to-month figures also fell 2.06 percent, marking a return to a downward trend after a brief uptick in May that suggested a sign of recovery.“The recovery may take quite a long time,” Suhariyanto, the head of BPS, said in a virtual presser on Monday.Despite having yet to bring the coronavirus under control, Indonesia is seeking to speed up the recovery of tourism by reopening Bali, a world-renowned tourist destination. Domestic travelers could visit Bali from July 31 and international visitors will be permitted starting from Sept. 11.With more than 82,000 visitors, Timor Leste accounted for around half of all foreign arrivals in June, followed by Malaysia with around 62,760 visitors and China with more than 2,000 visitors.“We are still seeing a negative year-on-year change in all foreign tourist [arrivals],” said Suhariyanto.“There was an uptick, but things are still far from normal, so we still need to work hard to attract foreign tourists to Indonesia. The key is the end of the pandemic and compliance with health protocols.”With most domestic and international travel having ceased, the occupancy rate of star hotels across Indonesia remained low at 19.70 percent in June, a drop of 32.57 percentage points from June of 2019.“The occupancy rate is not only about foreign tourists, but also about domestic tourists and business trips,” said the BPS head.The pandemic has cost the hotel and restaurant industry almost Rp 70 trillion (US$4.76 billion) and the aviation and tour industry Rp 15 trillion, according to data compiled last month by the Indonesian Hotel and Restaurant Association (PHRI).Most entry points to Indonesia continued to record declines in foreign arrivals in June, with a few exceptions like Soekarno-Hatta International Airport in Banten, which saw a 130.13 percent monthly increase, and Juanda International Airport in East Java, which saw a 708.33 percent monthly increase, following the relaxation of large-scale social restrictions.Read also: ASEAN hotel associations endorse travel bubbleTopics :last_img read more

Second Phase of Zenith Bank League Dunks off in Asaba

first_imgThe second phase of the Zenith Bank Women Basketball League is expected to begin today at the basketball court of the Asaba Township Stadium, Delta State as the race for the final-8 playoff gathers momentum.The flagship Nigerian women league organised by the Nigeria Basketball Federation (NBBF) will involve 18 clubs paired into Group A and Group B.Defending champion, Dolphins Basketball Club will look to consolidate its hold of group-A as it will do battles against eight other teams in the group which comprises of four-time champions of the league, First Deepwater basketball who is currently placed fifth in the group with three wins from eight games played at the first phase in Abuja. Other teams in group-A are host of second phase Delta Force basketball club, Nigeria Customs basketball team, GT 2000 of Kaduna, Zamfara Babes, AHIP Queens of Kano Oluyole Babes of Ibadan and Nigeria Immigration basketball team.Leading group-B is Nigeria most decorated women team, First Bank basketball club with six titles of the Zenith Bank Women league, the Elephant Girls is set to continue from where it left off from the Abuja-First-Phase but might face some opposition from rejuvenated IGP Queens of Lagos.Others in the group that might want to challenge the dominance of the two-time Africa Champions includes inform Plateau Rocks of Jos, Benue Princess, FCT Angels of Abuja, Sunshine Angels of Akure, Nasarawa Amazons, Taraba Hurricanes and Enugu Coal City side.Customs Head Coach, Abdulrahman Mohammed says the border-ladies are back to her old form which saw it share the local space with First Bank in the late nineties.The 2006 Nigeria senior men national team, D’Tigers captain to the Melbourne Commonwealth Games declared that Customs are ready to fight for the 2016 Zenith Bank league title.He dismisses the insinuation that the league is a two-way horse race between the defending champion, Dolphins and former champion First Bank urging both sides (Dolphins and First Bank) to be weary of other teams.The Gombe-state born basketball tactician who was part of Nigeria coaching crew that won the 2015 Afrobasket in Rades Tunisia want other corporate bodies to emulate Zenith Bank whose platform has catapult Nigeria women basketball to greater height.“Dolphins and First Bank should stop thinking that other teams in the league are just there to make up the numbers as they would shocked when the real competition begin when we gets to the final-8.“The sponsor – Zenith Bank has done so well for Nigeria women basketball and one must also commend NBBF for the superb increase in this year’s grant to teams, I want to appeal to other corporate organisations in Nigeria to copy from what Zenith Bank has contributed to the lives of hundreds of Nigerian women through the continuous sponsorship of the women league in the last twelve seasons.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegramlast_img read more

Europe’s Top Coaches Want Away Goal Rule Scrapped

first_imgManchester United boss Jose Mourinho and Arsenal’s Unai Emery were both in attendance at the summit, along with Napoli’s Carlo Ancelotti, PSG boss Thomas Tuchel, new Real Madrid manager Julen Lopetegui, Atletico Madrid’s Diego Simeone, Juventus coach Massimiliano Allegri and Emery’s Arsenal predecessor Arsene Wenger.“The coaches think that scoring goals away is not as difficult as it was in the past,” UEFA’s Deputy General Secretary Giorgio Marchetti stated while addressing reporters.“They think the rule should be reviewed and that’s what we will do.”He added that the managers now see the rule counter-productive as it encouraged home teams to play defensive football to try and prevent a costly away goal.The rule was initially introduced 53 years ago to prevent the staging of multiple replays when matches were deadlocked, and as a fairer way to decide games at a time when matches could also be decided by the toss of a coin.The summit also heard that coaches would like to see European transfer windows close at the same time, prior to the start of the season.Both England and Italy’s top-flights closed their windows before the start of the 2018/19 season, but Spain, France and Germany proceeded until August 31.“The coaches are of an opinion that there should be a unified window and the window should close before the competition starts,” said Marchetti.“The idea would be to try and bring them into line.”Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram *Call for uniform transfer windowEurope’s leading managers have called for an end to the away goals rule, which has been a staple of UEFA’s competitions for over 50 years.The annual gathering of top coaches in Switzerland heard that top bosses want the rule scrapped, citing that football has moved on since it was first introduced in the Cup Winners’ Cup in 1965.last_img read more

Serena wins first match since Wimbledon final, Osaka advance

first_imgSerena Williams defeated Belgium’s Elise Mertens on Wednesday to reach the third round at the WTA Toronto tournamentToronto, Canada | AFP |  Serena Williams looked solid in her first match since losing the Wimbledon final, defeating 20th-ranked Elise Mertens of Belgium 6-3, 6-3 on Wednesday at the WTA Toronto tournament.The 37-year-old American, one crown shy of a record-tying 24th Grand Slam singles title, advanced in 75 minutes at her first US Open hardcourt tuneup event.“I feel like my movement is great — been working on my fitness, so I felt like it really was able to shine through today,” Williams said.“I’m loving going out there and I’m loving kind of running. So it’s a good thing.”Also moving into the third round was Japan’s Naomi Osaka, the reigning US and Australian Open champion. She won after taking the first set 6-2 when Germany’s Tatjana Maria retired with a left abdominal injury.With Osaka’s triumph, Australian Ashleigh Barty was ensured of being dethroned next week as world number one, although it could be Czech Kristyna Pliskova instead of Osaka who swipes the top spot.Williams, ranked 10th, seeks her fourth WTA Canada crown after 2001, 2011 and 2013 and improved her match record at the event to 31-4, winning half the 10 break points she earned against Mertens.“Now that I’m just injury-free, I’m just enjoying being able to train, and I haven’t been able to do it since January, really,” Williams said.“So I just think that the fact that I can train and practice and get in the gym is really going to be helpful for me.”Mertens broke for a 2-1 lead but Williams answered in the sixth game to pull level at 3-3.“I know when I got down one break I got real negative,” Williams said. “I don’t know what happened on the first time I got down. (She) just played really well. She’s obviously a really good player. I just needed to just double down and get more focused.”Next in the path of the former world number one will be Russian qualifier Ekaterina Alexandrova, who eliminated China’s Zhang Shuai 6-4, 6-3. Osaka had not played a match since losing to Yulia Putintseva in the first round at Wimbledon.“I thought I played really well despite the fact that we only played one set,” Osaka said. “I was able to do what I wanted, which was go for the shots that I had the opportunity to.“And, of course, there were a couple unforced errors, but I think that’s part of the process.“For me, I’m just happy that it was my first match in a while and I was able to get in the groove of things quickly.”The victory gives Osaka the inside track on taking the top spot in Monday’s new rankings.– Pliskova eyes No. 1 –Pliskova could overtake Barty, the French Open champion who lost in Toronto on Tuesday, and Osaka both after beating 37th-ranked American Alison Riske 6-4, 6-7 (4/7), 6-2.The 27-year-old Czech must reach the semi-finals for any chance at taking world number one, but if Osaka makes the last eight, Pliskova must reach the final to have a hope at being number one next week.Pliskova will next play Estonia’s 19th-ranked Anett Kontaveit, who made the third round when Spain’s Carla Suarez Navarro retired with an injury at 7-5, 3-1 down.Romanian fourth seed Simona Halep outlasted American Jennifer Brady 4-6, 7-5, 7-6 (7/5).Ukraine teen Dayana Yastremska beat two-time major winner and former number one Victoria Azarenka 7-5, 7-5.Share on: WhatsApplast_img read more

Miami commissioner to postpone Ultra Music Festival due to coronavirus

first_imgCity of Miami commissioner Joe Carollo, and Mayor Francis Suarez spoke at a meeting at Miami City Hall in Coconut Grove Wednesday morning asking for the Ultra Music Festival to be postponed to protect attendees from the coronavirus.The huge music festival that brings a ton of money to the city each year will likely be postponed until 2021.“We’re going to be discussing with them the possibility of postponing the event, similar to what they’ve done in other parts of the world,” Suarez said. “As was mentioned, this event is very unique because you have people traveling from over 100 countries. Our decisions in the city are always going to be guided by protecting the citizens of this city.”It is unclear if ticket buyers will get a full refund. City officials say an official announcement is expected Friday.last_img read more